Research Home > Research Studies
NRG Cancer Prevention Committee
PI is seeking potential sites to participate in a prospective, randomized, non-blinded clinical trial enrolling women ages 45-60, with a BMI >40 to determine the effect of LNG-IUS in reducing the incidence of atypical hyperplasia (EIN) or endometrial cancer in a high-risk population after 6 years.
This study seeks to evaluate an effective and acceptable prevention method for women at high-risk of developing endometrial cancer. The trial is a prospective, randomized, non-blinded clinical trial enrolling women ages 45-60, with a BMI >40. The primary objective of the study is to determine the effect of LNG-IUS in reducing the incidence of atypical hyperplasia (EIN) or endometrial cancer after 6 years. Secondary objectives include an impact analysis of the LNG-IUS on health-related quality of life and its cost-effectiveness, as well as the development of predictive biomarkers using endometrial tissue, blood samples, urine samples and vaginal swabs. A total sample size of 1,600 participants (800 per group) will have 80% statistical power to detect a 50% reduction.
Publicizing Your Active Research Studies
Do you or your institution have an active research study that is applicable to academic specialists in general obstetrics and gynecology? SASGOG is happy to promote research studies to our members. Here’s what you’ll need:
- Study is submitted by a Supporting Institution, or one of the study investigators is a SASGOG member.
- A copy of the approved IRB.
- A descriptive title of the study and a brief description of the study.
- A link to the study survey and a link to a website that has more information about the survey.
- The start and end date of the study survey.
Submit information about your research study via the button below.